該基因編碼的蛋白屬于膜相關鳥苷酸激酶（maguk）家族，是一類在質膜特定區域組裝多蛋白復合物的分子支架蛋白。該蛋白也是card蛋白家族的一員，card蛋白家族的定義是攜帶一個特征性的caspase相關募集域（card）。該蛋白具有與card14蛋白相似的結構域。這兩種蛋白的card結構域都被證明與bcl10有特異性的相互作用，bcl10是一種已知的對細胞凋亡和nf-kappab活化起積極調節作用的蛋白。當在細胞中表達時，該蛋白激活nf-kappab并誘導bcl10磷酸化。[由RefSeq提供，2008年7月]
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]