該基因編碼的蛋白質屬于irf（interferon regulatory factor）轉錄因子家族，具有獨特的色氨酸五肽重復序列dna結合域。irfs在調節干擾素對病毒感染的應答和調節干擾素誘導基因方面具有重要作用。這個家族成員是淋巴細胞特異性的，負性調節toll樣受體（tlr）信號，這是激活先天性和適應性免疫系統的核心。涉及該基因和igh基因座t（6；14）（p25；q32）的染色體易位可能是多發性骨髓瘤的病因。另外，已經發現該基因的剪接轉錄變體。[由RefSeq提供，2010年8月]
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]