腎上腺素受體及其配體，即腎上腺素，介導許多發育過程，特別是在神經系統。根據它們的結構和序列關系，腎上腺素可分為通過糖基磷脂酰肌醇鍵固定在膜上的腎上腺素-A（EFNA）類和跨膜蛋白腎上腺素-B（EFNB）類。eph受體家族根據其胞外結構域序列的相似性和與ephrin-a和ephrin-b配體結合的親和力可分為2類。腎上腺素受體是酪氨酸激酶（rtk）受體家族中最大的亞群。這個基因編碼的蛋白質是腎上腺素b家族成員的受體。[由RefSeq提供，2008年7月]
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]