該基因編碼一個含有kelch-1樣結構域的蛋白質，以及一個btb/poz結構域。kelch樣ech相關蛋白1以氧化還原敏感的方式與nf-e2相關因子2相互作用，胞漿中的蛋白解離后，nf-e2相關因子2轉運到細胞核。這種相互作用導致γ-谷氨酰半胱氨酸合成酶催化亞基的表達。已發現該基因的兩個編碼相同亞型的選擇性剪接轉錄變體。[由RefSeq提供，2008年7月]
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]