axin相關蛋白axin2可能在wnt信號通路中調節β連環蛋白的穩定性方面起重要作用，與其嚙齒動物同源物鼠導蛋白/大鼠axil類似。在小鼠中，Conductin組織了APC（結腸腺瘤性息肉病）、β-連環蛋白、糖原合成酶激酶3-β和Conductin的多蛋白復合物，導致β-連環蛋白降解。顯然，β連環蛋白的放松調節是許多惡性腫瘤發生的一個重要事件。axin2基因已被定位到17q23-q24，該區域在乳腺癌、神經母細胞瘤和其他腫瘤中顯示出頻繁的雜合性缺失。該基因突變與大腸癌錯配修復缺陷有關。[由RefSeq提供，2008年7月]
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]