該基因編碼的蛋白是成纖維細胞生長因子（fgf）家族的一員。fgf家族成員具有廣泛的有絲分裂和細胞存活活性，參與胚胎發育、細胞生長、形態發生、組織修復、腫瘤生長和侵襲等多種生物學過程。該基因通過其致癌轉化活性鑒定。這個基因和另一種致癌生長因子fgf3，位于11號染色體上。兩種基因在不同類型的人類腫瘤中同時擴增。對小鼠同源物的研究表明，通過聲刺猬（shh）信號途徑，在骨形態發生和肢體發育中發揮作用。[由RefSeq提供，2008年7月]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]