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  • 發布時間:2022-07-19 14:16 原文鏈接: 受體酪氨酸激酶信號通路相關BRD4

    該基因編碼的蛋白質與小鼠蛋白MCAP(有絲分裂過程中與染色體相關)和人類Ring3蛋白(絲氨酸/蘇氨酸激酶)同源。每一種蛋白質都包含兩個溴域,一個保守的序列基序,可能參與染色質靶向。該基因被認為是T(15;19)易位的19號染色體靶基因(q13;p13.1),它定義了年輕人的上呼吸道癌。已經描述了兩個選擇性剪接轉錄變體。
    The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.

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