曹雪濤院士回復“數據造假”質疑對論文重復性充滿信心

　　針對Elisabeth Bik發文質疑2008年發表在Blood雜志上的文章數據，曹雪濤院士本人進行了回應：

　　Elisabeth Bik提出的質疑：

　　Figure 1A. The "unstimulated" and "LPS" panels in the BAPTA-AM row appear to look unexpectedly similar. Shown with red boxes. Could the authors please check?

　　以下為曹雪濤院士的回復：

　　Dear Dr. Bik,

　　I’m writing to you in response to recent inquiries you posted with regard to mentioned studies conducted at the National Key Laboratory of Medical Immunology and Institute of Immunology at the Second Military Medical University, with me being the corresponding author.

　　對于您最近發表的關于在第二軍醫大學醫學免疫學國家重點實驗室和免疫學研究所進行的上述研究的詢問，我寫信給您，我是通訊作者。

　　I appreciate your interest in our work and your commitment to protecting the accuracy of scientific records and the integrity of research pursuit. They are of utmost importance to me all along as well. Upon being notified of your inquiries, I have made them our highest priority and immediately took steps to look into the concerns you raised with the team and collaborators and carefully re-examined our manuscripts and raw data and lab records. We’ll work with the relevant journal editorial office(s) immediately if our investigation indicates any risk to the highest degree of accuracy of the published records.（首要任務就是自查，如果有問題，就撤稿！）

　　感謝您對我們工作的興趣以及您對保護科學記錄的準確性和研究追求的完整性的承諾。一直以來，它們對我也至關重要。在收到您的詢問后，我將其列為我們的首要任務，并立即采取措施調查您與團隊和合作者提出的問題，并仔細地重新檢查了我們的手稿，原始數據和實驗室記錄。如果我們的調查顯示所發布記錄的最高準確性存在任何風險，我們將立即與相關的期刊編輯部合作。

　　Based on our analyses up to this point (still ongoing) and additional feedback we received from colleagues and peers, I would like to add that I remain confident about the validity and strength of the scientific conclusions made in those publications and our work’s reproducibility. Nevertheless, there is no excuse for any lapse in supervision or laboratory leadership and the concerns you raised serve as a fresh reminder to me just how important my role and responsibility are as mentor, supervisor, and lab leader； and how I might have fallen short. I feel therefore very heavy-hearted and tremendously sorry, to my current and former students, my staff and colleagues, my peers, and the larger community. I most sincerely apologize for any oversight on my part and any inconvenience it might have caused. I’ll use this as an invaluable learning opportunity to do better not only in advancing science, but also in safeguarding the accuracy and integrity of science.

　　根據到目前為止的分析（仍在進行中）以及從同事和同行那里獲得的其他反饋，我想補充一點，我對這些出版物中得出的科學結論的有效性和優勢以及我們工作的可重復性仍然充滿信心。然而，監督或實驗室領導地位的任何失調都是沒有借口的，您提出的疑慮再次提醒我，我作為指導者，主管和實驗室領導者的角色和責任是多么重要；以及我可能無法做到的事情。因此，對于我現在和以前的學生，我的員工和同事，我的同齡人以及整個社區，我感到非常心情沉重，并感到非常抱歉。對于我的疏忽以及給您帶來的不便，我深表歉意。

　　Yours sincerely,

　　Xuetao Cao

　　在信中，曹雪濤院士表達了歉意，特別指出，作為領導者難辭其咎。但同時也強調對實驗的重復性充滿信心。

　　作為本土培養的免疫學界標桿人物，無數人的偶像，曹雪濤院士及時回復質疑，直面問題，就事論事，我只能說，這比過往其他好多被質疑的“心虛教授”不知強多少...

　　但是作為科研數據的嚴謹性來說，此次事件也給曹雪濤院士團隊敲響了警鐘，高處不勝寒，作為標桿人物，任何一點瑕疵都會被放大，即使對文章的數據可重復性胸有成竹。

　　曹雪濤院士簡介

　　曹雪濤院士1964年出生于山東省濟南市，17歲就讀于第二軍醫大學海醫系本科，22歲在第二軍醫大學攻讀碩士研究生，26歲時碩士畢業于第二軍醫大學。同在26歲時被授予博士學位，28歲破格晉升為當時我國最年輕的醫學教授。32歲晉升為博士生導師，33歲擔任全軍免疫與基因治療重點實驗室主任，41歲成為當時最年輕的中國工程院院士。此外，他還是當時我國最年輕的將軍。目前是南開大學校長。