直播預告|南科大、密歇根州立大學等三位專家報告

直播時間：2024年5月7日（周二）20:00-22:00

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北京時間5月7日晚八點，iCANX Youth Talks第五十四期邀請到了南方科技大學劉吉，密歇根州立大學劉心悅，南方科技大學肖凱三位教授主講，澳門大學賈艷偉作為主持人，中國科學技術大學王柳，中國科學院納米能源研究所唐偉擔任嘉賓，期待你一起加入這場知識盛宴。

【嘉賓介紹】

劉吉

南方科技大學

功能水凝膠電子界面

【Abstract】

Hydrogel materials are highly similar in structure and composition to biological tissues, and are emerged as one of the most ideal materials for the bioelectronics interfacing. Traditional synthetic hydrogels exhibit low strength and are prone to brittle fracture. It remains challenge to form seamless interface between the hydrogel materials and biological tissues, due to the presence of free water at the interface, which greatly hampers their in vivo applications. To address these challenges, we have constructed a series of functional hydrogel materials and bioelectronic interfaces through multi-scale structural design and fabrication, in order to provide potential solutions to challenges in the fields of bioelectronics and tissue engineering.

水凝膠材料和生物組織在結構和組成上有著高度的相似性，被認為是人體組織與生物電子交互界面的最理想材料之一。傳統合成水凝膠強度低，易發生脆性斷裂；在潮濕的生理環境下，由于界面游離水的存在，水凝膠材料很難與生物組織形成有效的粘合界面，很大程度上限制了它們的應用。針對上述挑戰，我們通過多尺度結構設計，構筑了一系列功能特異性水凝膠材料和生物電子界面，以滿足不同場景的應用需求，為生物電子和組織工程等領域的挑戰提供潛在的解決策略。

【BIOGRAPHY】

Dr Ji Liu is currently an Associate Professor in the Department of Mechanical and Energy Engineering, Southern University of Science and Technology (Sustech, China). He obtained his PhD from the University of Liege (Belgium) and University of Bordeaux (France) under the framework of Erasmus Mundus Joint PhD program in 2013. Prior to joining Sustech, he conducted post-doc research in the University of Cambridge, Massachusetts Institute of Technology and Harvard Medical School. His research interest includes soft material engineering, extreme mechanics, tissue engineering, flexible electronics, and has published over 50 papers in those journals like Sci. Adv., Nat. Commun., PNAS, Adv. Mater., JACS, Angew. Chem. Int. Ed. He is also the recipient of several awards, including Nano Research Young Innovators (NR45, 2023) Awards, Innovators Under 35 of China by MIT Technology Review (2020), Guangdong Pearl River Talents Program Introduces High-Level Talents (2020), Overseas High-Caliber Personnel in ShenZhen (2020), Young Investigator Award by Japan Polymer Group (2017), Marie-Curie Research Fellow (2015), etc.

劉吉，南方科技大學機械與能源工程系研究員，博士生導師和課題組長。劉吉博士在歐盟Erasmus Mundus聯合博士獎學金的資助下，于2013年底在法國波爾多大學和比利時列日大學獲得博士學位；2014-2019年先后在瑪麗居里基金會和美國國防高級研究計劃局等項目資助下在劍橋大學、麻省理工學院和哈佛醫學院從事研究工作；2019年9月加入加入南方科技大學。劉吉博士的研究興趣包括軟材料力學，軟材料加工及器件化、動態表界面、3D打印、人體技術相關的柔性電子等。先后在Sci. Adv., Nat. Commun., PNAS, Adv. Mater., JACS, Angew. Chem. Int. Ed.,等期刊上發表文章50余篇；先后獲納米研究青年科學家獎(NR45 Awards, 2023)、英國材料礦業與礦物學會會士(2021)、《麻省理工科技評論》中國區“35歲以下科技創新35人”(2020)、珠江人才引進高層次人才青年項目(2020)、深圳市海外高層次人才(2020)、日本高分子協會青年學者獎(2017)、瑪麗居里學者(2015)等榮譽。

劉心悅

密歇根州立大學

設計水凝膠以調控光子和物質傳輸

【ABSTRACT】

The capability to manage transport processes opens a myriad of applications, such as fiber optic communication, efficient water purification, and building thermal insulation. While hydrogels have emerged as engineering materials of significant interest due to their superior mechanical compliance and water-retaining capacity, their potential in modulating light and mass transport remains largely unexplored. Our research team focuses on developing hydrogels that can precisely control light propagation and chemical diffusion. The first representative work is designing hydrogels with high transmittance and a high refractive index to minimize the photon transport loss even under dynamic conditions. Through the controlled growth of polymeric nanocrystalline domains within the hydrogels, we have fabricated hydrogel materials with optimal absorption, scattering and refractive properties and mechanical resilience. Such material innovation led to the creation of a hydrogel optical fiber with a core-cladding structure, facilitating flexible and efficient photon propagation. A notable application of this technology is the implantation of hydrogel optical fibers for optogenetic control. These fibers effectively deliver light to peripheral nerves for optogenetic control and allow for continuous stretching without impeding natural animal behaviors. The second aspect focuses on engineering the polymer network architectures in hydrogels to enhance water diffusion during swelling and sorption. This has been achieved by introducing additional polymer transition between crystalline and amorphous states to amplify enthalpic gains from polymer-solvent interactions. We demonstrated the applications of hydrogels with improved water transport including atmospheric water harvesting and super-expandable intragastric balloons. Lastly, I will discuss the ongoing project that hydrogels are engineered with high-specificity biomolecular interactions, ensuring selective permeability of them. This has significant potential in biosensing, drug delivery, and cell culture.

傳遞過程的控制在很多領域有著廣泛應用，比如光纖通訊里的光子傳輸，以及凈化水系統的離子和水分子的傳遞。水凝膠材料擁有卓越的機械性能和保水能力，近年來成為引人注目的工程材料；但運用水凝膠對光和物質傳輸進行調節的潛力仍然未被充分開發。我們研究團隊專注于研究能夠精確控制光傳播和化學擴散的水凝膠。第一項代表性工作是設計具有高透光率和高折射率的水凝膠，來減小動態加載過程中的的光學損失。通過在水凝膠中控制聚合物納米晶體域的生長，我們制造了具有最優吸收、散射、折射特性和機械彈性的水凝膠材料。基于這項材料創新，我們設計了核殼結構的水凝膠光纖，促進了靈活而高效的光學傳輸。這項技術的一個顯著應用是周圍神經的光遺傳控制：這些水凝膠光纖能在動物體內有效地將光傳遞到周圍神經，不會對動物的運動有額外影響。第二個工作是關于改進水凝膠中聚合物網絡結構來增強其膨脹和吸附過程中的水分擴散。通過引入晶體與非晶態之間的聚合物過渡，放大了聚合物-溶劑相互作用的焓增益。通過改進水凝膠里面的分子傳遞，我們實現了大氣水收集和可擴展的胃內氣球。總的來說，我們正致力于研究水凝膠基材中的分子和光子傳遞過程，這些研究將在生物傳感、藥物傳遞和環境工程中發揮重要作用。

【BIOGRAPHY】

Xinyue Liu is an Assistant Professor in the Department of Chemical Engineering and Materials Science at Michigan State University. She received her Ph.D. degree in Mechanical Engineering from Massachusetts Institute of Technology in 2021, and her bachelor’s degree from Sichuan University in 2015. From 2022 to 2023, she was a postdoctoral fellow in Mechanical Engineering at Massachusetts Institute of Technology. She has published over 20 papers in numerous high-impact journals, including Nature Methods, Nature Communications, Nature Chemical Biology, Matter, Science Advances, PNAS, Advanced Materials. Her research group currently focuses on hydrogel materials and devices as the new paradigm to control mass transport and light transmission for biomedical and environmental applications. As of April 2024, her research has been cited more than 5000 times with an H-index of 55. She was awarded with Forbes Asia 30 Under 30, MRS Graduate Student Award, Chinese Government Award for Outstanding Students.

劉心悅，美國密歇根州立大學化工材料系助理教授。劉心悅2015年于四川大學本科畢業，此后于2021年在美國麻省理工大學獲得機械工程博士學位。2022年到2023年期間，曾在美國麻省理工大學系進行博士后研究。她在一些高影響力期刊上發表20余篇論文，其中包括Nature Methods, Nature Communications, Nature Chemical Biology, Matter, Science Advances, PNAS, Advanced Materials等刊物。她的課題組正致力于研究水凝膠材料以及器件作為用于醫療、農業、環境實踐的新一代技術。截止2024年4月，她的工作被引用5000 余次，H指數21。她還被授予Forbes亞洲30 Under 30獎，MRS研究生獎，中國CSC海外優秀學生獎等獎項。

肖凱

南方科技大學

神經仿生離子信息材料與器件

【ABSTRACT】

The language of intelligent life is "ions", and the language of artificial intelligence is "electrons". To build a high-throughput and low-power brain-like computing system, the "Neuro-inspired Materials and Devices Lab" conducts interdisciplinary research of ionic energy and computing materials and devices involving chemistry, materials, information, and biology, which has the potential to break through the barriers of information exchange between intelligent life and artificial intelligence. We constructed a bioinspired multi-scale ion transport system, including nanofluidic system and soft ionic conductor system, revealed the interaction law between ion transport behavior and material structure/interface, fabricated a series of ionic energy devices (e.g., ion pump/ion-electron Coulomb drag energy generator) and ionic brain-like devices (e.g., ionic memristor/ionic neuromorphic chips). We hope the energy and neuromorphic devices using "ions" as language have the potential for realizing brain-machine hybrid intelligence.

離子在智能生命體中至關重要，神經細胞中動作電位的產生、植物細胞光合作用、皮膚的壓力感知等都和離子的定向傳輸密切相關。可以說，智能生命的語言是“離子”，而人工智能的語言是“電子”。因此，如何構筑基于離子傳輸的類腦計算器件，從而架起智能生命和仿生體系的橋梁，是我們未來面向腦-機混合智能的一個重要挑戰。該研究方向是受生物蛋白質通道及其離子輸運功能的啟發，近年來隨著納米科學與信息技術的發展而興起的最前沿和最活躍的課題之一。我們課題組圍繞“神經仿生材料、類腦計算器件、神經調控技術”這一主題開展化學、材料、信息、生物等多學科交叉研究。通過仿生的手段構筑了一系列離子傳輸材料，通過調控其結構和界面性質，探究了限域空間/界面內可控離子傳輸的機制，實現了類腦的多種脈沖放電功能；在此基礎上，基于深度神經網絡（DNN）和脈沖神經網絡的（SNN）的新型類腦算法，實現了低能耗、高通量的類腦計算；通過在多尺度范圍內構筑基于離子傳輸的神經擬態器件，實現了以“離子”為語言的類腦計算器件的構筑并用于生物信號/信息調控和“人工智能-生物智能”無障礙溝通。

【BIOGRAPHY】

Dr. Kai Xiao is an associate professor at the Department of Biomedical Engineering, Southern University of Science and Technology, China. Kai Xiao received his bachelors degree from Jilin University (Changchun, China) in 2012, and his PhD from the Institute of Chemistry, Chinese Academy of Sciences (ICCAS, China) in 2017. After that, he moved to the Max Planck Institute of Colloids and Interfaces (MPIKG, Germany) working as an Alexander von Humboldt (AvH) Fellow. From 2021, he works as an Associate Professor at the Southern University of Science and Technology (SUSTech, China), and leads a research group of "Neuro-inspired Materials and Devices Lab". He has authored over 60 academic papers published in peer-reviewed journals and two book chapters, with citations of over 4000. His research interest lies in nanofluidic, ionic soft materials, and ionic energy/neuromorphic devices.

肖凱，南方科技大學生物醫學工程系副教授，創新材料研究院兼職教授，博士生導師，洪堡學者，深圳市鵬城特聘教授。2012年于吉林大學獲得學士學位，2017年于中國科學院化學研究所獲得博士學位，2017年受洪堡基金會資助于德國馬普膠體界面研究所從事博士后研究，2020年加入德國萊布尼茨固體與材料研究所從事博士后研究。2021年9月加入南方科技大學生物醫學工程系。在Nat. Commun., Sci. Adv., Natl. Sci. Rev., Angew. Chem. Int. Ed., Adv. Mater., JACS等雜志發表學術論文60余篇，撰寫Wiley 出版社百科全書《Kirk-Othmer Encyclopedia of Chemical Technology》等兩章節。現任《Chinese Chemical Letter》和《Journal of Bionic Engineering》青年編委，入選2022年“全球前2%頂尖科學家”榜單，曾獲德國“洪堡學者”獎學金、中國科學院優秀博士畢業論文、中國科學院院長優秀獎、朱李月華獎學金、唐敖慶化學獎學金、國際納米科技與納米醫學峰會優秀青年科學家等榮譽和獎勵。

【主持人】

賈艷偉

澳門大學

【研討嘉賓】

王柳

中國科學技術大學

唐偉

中國科學院納米能源研究所