該基因編碼的蛋白質是atp結合盒（abc）轉運蛋白超家族的成員。abc蛋白通過細胞外和細胞內的膜運輸各種分子。abc基因分為七個不同的亞家族（abc1，mdr/tap，mrp，ald，oabp，gcn20，white）。這種全轉運蛋白是mrp亞家族的一員，參與多藥耐藥。該蛋白作為一種多特異性有機陰離子轉運蛋白，以氧化戊二酮、半胱氨酸白三烯和活化的黃曲霉毒素b1為底物。這種蛋白質還運輸葡萄糖醛酸和類固醇激素和膽鹽的硫酸鹽結合物。該基因的選擇性剪接變體已經被描述，但其全長性質未知。[由RefSeq提供，2012年4月]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]