這個基因編碼分泌糖蛋白slit家族的一個成員，它是免疫球蛋白受體robo家族的配體。slit蛋白在軸突引導和神經元遷移中起著高度保守的作用，在包括白細胞遷移在內的其他細胞遷移過程中也可能發揮作用。slit家族成員具有一個n末端信號肽、四個富含亮氨酸重復序列、九個表皮生長因子重復序列和一個c末端半胱氨酸結的特征。這種蛋白質的蛋白水解過程產生一個N-末端片段，包含四個富含亮氨酸的重復序列和五個表皮生長因子重復序列，以及一個C-末端片段，包含四個表皮生長因子重復序列和半胱氨酸結。全長和裂解的蛋白質都是在細胞外分泌的，在軸突排斥和其他特定過程中發揮作用。選擇性剪接導致多個轉錄變體。[由RefSeq提供，2015年9月]
This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]