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  • 發布時間:2022-07-18 16:58 原文鏈接: 經典PI3K/AKT/mTOR信號通路相關MCL1

    該基因編碼一種抗凋亡蛋白,屬于bcl-2家族。選擇性剪接導致多個轉錄變體。最長的基因產物(亞型1)通過抑制細胞凋亡來增強細胞存活,而交替剪接的較短的基因產物(亞型2和亞型3)則促進細胞凋亡并誘導死亡。[由RefSeq提供,2010年10月]
    This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

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