20點直播|東京大學教授分享醫用新型微針

原文地址：http://news.sciencenet.cn/htmlnews/2023/4/499638.shtm

直播時間：2023年4月28日（周五）20:00-21:30

直播平臺：

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北京時間2023年4月28日晚八點，iCANX Talks 第141期將在iCANX平臺上線！本期我們邀請到東京大學Beomjoon Kim教授進行分享醫用生物分子傳輸微針系統！更多精彩，敬請期待！

【直播介紹】

Beomjoon Kim

The University of Tokyo

Biomolecular Needling Systems for Medicals

【Abstract】

Recently, in the transdermal drug delivery methods, the microneedle-mediated drug delivery system (DDS) has been developed to replace the hypodermic injection-mediated DDS, to provide painless self-administration of biological drug with patient friendly manner. Dissoluble microneedles are attracting many attentions as it has several advantages such as no needle-related risks. We have developed new fabrication methods for biodegradable microneedles array patches (MAPs), which are different with the conventional fabrication ones, such as stepwise casting method. Here, new transdermal drug delivery system by using dissoluble micro needle patch will be introduced. We also develop several aspects of bio-sensors components to accomplish portable Point-of-Care diagnostic devices, which are disposal, user-friendly, low-cost, and highly sensitive.

近年來，基于微針的透皮給藥系統已被開發出來，以取代皮下注射的給藥方式，為患者提供了一種無痛友好的自我給藥方法，其中，可溶性微針因其無針頭相關風險等優勢而備受關注。不同于傳統制備方法，我們開發了生物可降解微針陣列貼片的逐步鑄模法等新型制備技術，本次演講將介紹一種基于可溶性微針貼片的新型透皮給藥系統。同時微針還可用于生物信息檢測，我們開發了多種生物傳感器，并與微針集成為便攜式即時診斷器件，具有易于使用及處理、低成本和高靈敏度等諸多優點。

We fabricated porous microneedle on a paper substrate to develop a novel platform for direct integration of sensors. The device painlessly monitors fluid in the skin within seconds. Anyone can use the disposable patch without training, making it highly practical. Additionally, fabrication is easy, low cost, and the glucose sensor can be swapped for other paper-based sensors that monitor other important biomarkers.

通過在紙基板上制備多孔微針，我們開發出一種新型傳感器直接集成平臺，能夠在幾秒鐘內無痛檢測皮膚內的液體。任何人都可以不經培訓便能使用該一次性貼片，因此非常實用。此外，該貼片制造工藝簡單、成本低，并且葡萄糖傳感器可以替換為其它基于紙材的傳感器，以監測其它重要的生物標志物。

【BIOGRAPHY】

Beomjoon Kim is a Professor of Institute of Industrial Science, the University of Tokyo, Japan. Also, he is currently a director of LIMMS-KIKO, a director of CREMeB (Center for Research on Engineering in Medicine and Biology), and in charge as a chair of corporate sponsored research division of “Virological Medicine”, at I.I.S., the University of Tokyo. He received his B.E. degree from Seoul National University, Dept. of Mechanical Design and Production Eng., Korea, in 1993, and M.S., Ph.D. in Precision Engineering, from the University of Tokyo, Japan, in 1995 and 1998, respectively. He was a CNRS Associate Researcher in LPMO, Besancon, France (1998-99), and worked in MESA+ Research Institute, University of Twente (1999-2000).

金範埈教授就職于日本東京大學生產技術研究所，同時擔任LIMMS-KIKO和CREMeB（醫學和生物學工程研究中心）董事、“病毒醫學”研究部門主席。在教育背景方面，金教授于1993年在韓國首爾國立大學機械設計與制造工程系獲得學士學位，1995年和1998年分別獲得日本東京大學精密工學系碩士和博士學位。在工作經歷方面，金教授于1998-1999年在法國貝桑松物理與計量實驗室（LPMO）擔任副研究員，1999-2000年在荷蘭特文特大學MESA+納米技術研究所工作。

He was an Associate Professor in the Univ. of Tokyo (2000-2013), and was a co-director at the CIRMM/CNRS Paris office (2001-2003). He investigates several aspects of bio-sensors components to accomplish portable Point-of-Care diagnostic devices, which are disposal, user-friendly, low-cost, and highly sensitive. Moreover, he is interested to develop self-powered, energy harvesting micro sensors as well as smart monitoring system. Recently, main research topic is focused to study on new transdermal drug delivery system by using dissoluble micro needle patch. He has published 113 peer reviewed journal papers, 216 international conference papers, 204 domestic conference papers as well as tens of patents, books publications so far.