該基因通過其編碼蛋白與針對阿爾茨海默病患者腦勻漿制備的單克隆抗體的反應性進行鑒定。對原蛋白（胎兒alz-50活性克隆1，fac1）的分析表明，該蛋白可能參與轉錄調控，是一種含有dna結合區和鋅指基序的810a a蛋白。胎兒腦和神經退行性疾病患者中檢測到高水平的FAC1這個基因編碼的蛋白質實際上比最初想象的要大得多，而且它還含有一種蛋白質的C-末端溴代胺，在增殖過程中調節轉錄。編碼蛋白與果蠅nurf（核小體重塑因子）復合物的最大亞單位高度相似。在果蠅中，nurf復合物催化核小體在dna上滑動，并與序列特異性轉錄因子相互作用，是轉錄所需的染色質重塑所必需的。兩個編碼不同亞型的替代轉錄本已經被完全描述。[由RefSeq提供，2008年7月]
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]