這個基因編碼的蛋白質是一種質膜G蛋白偶聯受體，能感覺到循環鈣濃度的微小變化。編碼的蛋白質將這些信息與細胞內的信號傳導途徑結合起來，這些信號傳導途徑可以調節甲狀旁腺激素的分泌或腎離子的處理，因此這種蛋白質在維持礦物離子的穩態中起著至關重要的作用該基因突變是家族性低鈣血癥、新生兒重度甲狀旁腺功能亢進和常染色體顯性遺傳性低鈣血癥的原因。[由RefSeq提供，2017年8月]
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]