該基因編碼的蛋白屬于免疫球蛋白超家族，參與調節t細胞介導的免疫應答。研究表明，盡管該基因的轉錄本在正常組織和實體瘤中廣泛表達，但該蛋白只在腫瘤組織中優先表達。此外，我們還觀察到該轉錄本的3’utr含有mir29 microrna的靶位點，并且該蛋白的表達與mir29水平呈負相關，這表明mir29對該基因產物的表達具有調節作用。另外，已經發現該基因編碼不同亞型的剪接轉錄變體。[由RefSeq提供，2011年9月]
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]