在脊椎動物中，編碼一類轉錄因子的基因被稱為同源盒基因，它們在四條獨立的染色體上以a、b、c和d的形式存在。這些蛋白的表達在胚胎發育過程中受到時空調控。這個基因是7號染色體上一個簇的一部分，編碼一個DNA結合轉錄因子，它可以調節基因的表達、形態發生和分化。該基因與果蠅的腹部-B（Abd-B）基因高度相似導致該基因與nup98基因融合的特異性易位事件與髓系白血病的發生有關。在該基因與上游同源盒A10（HOXA10）基因之間存在閱讀轉錄。[ RefSeq，MAR 2011 ]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]