這個基因編碼胰腺β細胞功能的調節因子。它與小鼠c-jun氨基末端激酶（mapk8）的調節蛋白jip-1高度相似。該蛋白已被證明能阻止MAPK8介導的轉錄因子激活，并能減少IL-1β和MAP kinase激酶1（MEKK1）誘導的胰腺β細胞凋亡該蛋白也作為葡萄糖轉運蛋白GLUT2的DNA結合反式激活因子發揮作用據報道，RE1沉默轉錄因子（REST）抑制胰島素分泌β細胞中該基因的表達該基因在2型糖尿病家族中突變，因此被認為是2型糖尿病的易感基因[由RefSeq提供，2011年5月]
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]