這個基因編碼一種細胞骨架蛋白，這是組織肌動蛋白細胞骨架所必需的。這種蛋白質是含有肌動蛋白微絲的一種成分，它參與控制細胞的形狀、粘附和收縮。該基因多態性與1型胰腺癌易感性相關，也與心肌梗死風險相關。選擇性剪接導致多個轉錄變體。
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]