這個基因編碼的蛋白質是三部分基序（trim）家族的成員。裝飾圖案包括三個鋅結合域、一個環、一個B盒類型1和一個B盒類型2，以及一個卷曲的線圈區域。這種磷蛋白定位于核體，在那里作為轉錄因子和腫瘤抑制因子發揮作用。其表達與細胞周期相關，并調節p53對致癌信號的反應。該基因常與急性早幼粒細胞白血病（APL）相關的維甲酸受體α基因易位有關。這種基因的廣泛選擇性剪接導致蛋白質的中心和C端區域的幾種變異；所有的變異編碼相同的N端。另外，還發現了編碼不同亞型的剪接轉錄變體。
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.