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  • 發布時間:2022-08-22 10:22 原文鏈接: PRKCE基因編碼的功能和結構描述

    蛋白激酶C(PKC)是一個絲氨酸和蘇氨酸特異性蛋白激酶家族,可被鈣和第二信使甘油二酯激活pkc家族成員磷酸化多種蛋白質靶點,參與多種細胞信號傳導途徑。PKC家族成員也是一類腫瘤促進劑佛波酯的主要受體pkc家族的每個成員都有一個特定的表達譜,并被認為在細胞中發揮著獨特的作用。該基因編碼的蛋白是pkc家族成員之一。這種激酶參與了許多不同的細胞功能,如神經元通道激活、細胞凋亡、心肌缺血保護、熱休克反應以及胰島素分泌敲除小鼠的研究表明,這種激酶對于脂多糖(LPS)介導的激活巨噬細胞中的信號是重要的,并且還可能起到控制焦慮樣行為的作用。

    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.

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