該基因編碼的蛋白是蛋白酪氨酸磷酸酶（ptp）家族的一員。眾所周知，ptps是調節多種細胞過程的信號分子，包括細胞生長、分化、有絲分裂周期和癌基因轉化。該ptp具有含有5個纖維粘連蛋白iii型重復序列的胞外區域、單個跨膜區域和單個胞漿內催化結構域，因此代表ptp受體類型。該蛋白存在于所有造血系中，可能通過干擾磷脂酶cγ1的磷酸化和激活t細胞的連接蛋白來負調控t細胞受體信號。該蛋白也能使pdgfβ受體去磷酸化，可能參與uv誘導的信號轉導。已發現該基因編碼不同亞型的多個轉錄變體。
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.