這種基因產物是一種序列特異的單鏈dna結合蛋白。它優先與富含嘌呤元素PUR的單鏈結合,PUR存在于從酵母到人類的各種真核生物的復制起源和基因側翼區域因此,它參與了dna復制和轉錄的控制。該基因缺失與骨髓增生異常綜合征和急性髓性白血病有關。
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.