nf-kappa-b是一種廣泛存在的轉錄因子，參與多種生物學過程。它被特定的抑制劑以非活性狀態保存在細胞質中。當抑制劑降解時，nf-kappa-b移向細胞核并激活特定基因的轉錄。nf-kappa-b由結合到rel、rela或relb的nfkb1或nfkb2組成。nf-kappa-b最豐富的形式是nfkb1與該基因的產物rela復合。已經發現了四個編碼不同亞型的轉錄變體。
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.