跨膜信號轉導素sema6a在發育中的神經組織中表達，是丘腦皮質投射正常發育所必需的（Leighton等人，2001年[Pubmed 11242070]）。
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).