這個基因編碼sirtuin蛋白家族的一個成員，與酵母sir2蛋白同源。sirtuin家族成員以sirtuin核心域為特征，分為四類。人類sirtuin的功能尚未確定；然而，已知酵母sirtuin蛋白可調節表觀遺傳基因沉默和抑制RDNA的重組。研究表明，人sirtuins可能作為具有單ADP核糖轉移酶活性的細胞內調節蛋白發揮作用。該基因編碼的蛋白質包含在sirtuin家族的I類中。選擇性剪接導致多個轉錄變體。
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.