該基因編碼硫氧還蛋白結合蛋白，其是α-抑制素蛋白家族的成員。硫氧還蛋白是一種巰基氧化還原酶，它是細胞氧化還原信號的主要調節器，它保護細胞免受氧化應激。這種蛋白質抑制硫氧還蛋白的抗氧化功能，導致活性氧的積累和細胞應激。該蛋白還可以調節細胞代謝和內質網應激。這種蛋白質也可以作為一種腫瘤抑制因子。交替剪接導致多個轉錄變體。
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants.