Peptide-Based Drug Design: Methods and Protocols (Methods in Molecular Biology)
By Laszlo Otvos
Publisher: Humana Press
Number Of Pages: 304
Publication Date: 2008-09-12
ISBN-10 / ASIN: 1588299902
ISBN-13 / EAN: 9781588299901
Binding: Hardcover
Product Description:
Due to their high specificity and low toxicity profile, peptideshave once again become central to the development of new drugs. InPeptide-Based Drug Design: Methods and Protocols, expert researchersprovide a handbook which offers a selection of research and productiontools suitable for transforming a promising protein fragment orstand-alone native peptide into a pharmaceutically acceptablecomposition. The volume delves into contemporary, cutting-edge subjectssuch as hit isolation and target validation, computer-aided design,sequence modifications to satisfy pharmacologists, in vivo stabilityand imaging, and the actual production of difficult sequences. Writtenin the highly successful Methods in Molecular Biology? series format,chapters include readily reproducible, step-by-step laboratoryprotocols, lists of materials, and the Notes section, which highlightstips on troubleshooting and avoiding known pitfalls.
Comprehensive and up-to-date, Peptide-Based Drug Design: Methodsand Protocols shows its subject to be an independent science on therise, and provides scientists with a clear, concise guide forcontinuing this vital research.