SCIEX推出新C100HT生物制品分析系統,用于高通量糖基篩選

　　分析測試百科網訊 SCIEX 是生命科學分析技術領域的全球領導者, 2018年1月30日在馬薩諸塞州弗雷明漢宣布推出新C100HT，用于生物制藥領域的定量糖基篩選。結合使用SCIEX的獲獎技術快速糖基化學（fast glycan chemistry，快速糖分析的樣品前處理技術）, C100HT 使研究人員可以應對耗時的樣本準備和數據分析的挑戰, 使用強大的工作流，進行每天數以百計的糖基樣本篩選，獲得可視化的可操作性數據，而不需要耗時的解釋。

C100HT生物制品分析系統

　　SCIEX C100HT 高通量糖基篩選技術以先進的毛細管電泳硬件及用戶友好的軟件為基礎, 一個糖分析試劑盒配置為多達1,000次的分離, 12通道的毛細管試劑盒可并行處理樣品。糖基鑒定的結果可顯示在直觀的數據分析面板上, 一目了然地顯示通過/失敗的結果, 可對克隆篩選和細胞培養條件的優化進行實時決策。 C100HT 置于一個高度可調的移動小推車上, 使研究者可根據自己的實驗設施進行靈活的調節，便于在決策時定位分析。

　　使用C100HT 樣品制備化學技術，可在不到2小時內制備96個樣品, 可從大量樣本中快速篩選克隆，并實時進行細胞培養條件的優化, 從而顯著增加篩選出最佳克隆和最佳培養條件的可能性。使用自動糖基鑒定技術，無需花費繁瑣的糖基數據庫搜索時間, 最大限度地減少了人為錯誤和優化工作流的可能性。

　　"由于使用除滴度分析以外的其它信息，提升了克隆篩選和細胞培養條件優化的能力, 可進行更大規模的篩選, 提供更好的信息來選擇和開發有影響力的生物制劑。SCIEX高級產品經理Mark Lies說，"在克隆篩選和細胞培養條件優化過程中，糖基篩選是一個重要部分, 但過去它的限制是：有多少克隆能夠被篩選, 更不用說接下來的數據質量。C100HT是針對這一挑戰的解決方案, 包括簡化的樣本準備、直面挑戰的儀器設計，和有意義的可視化數據分析, 使研究人員能夠在任何情況下提高其工作流通量，給出可幫助快速決策的答案。”

　　SCIEX 的快速糖標簽和分析技術榮獲2016生物工藝國際 (BPI) "最佳技術應用獎-分析類", 以展示其與其它分析技術產生的新組合的強大功能。

關于SCIEX

　　SCIEX 幫助科學家和實驗室分析人員尋找解決方案來戰勝他們面臨的復雜分析挑戰，從而改善我們生存的世界。憑借在毛細管電泳色譜和液相色譜串聯質譜行業的知名地位和一流的服務與支持，公司成為全球數以萬計的科學家和實驗室分析人員值得信賴的合作伙伴，這些人員主要從事基礎研究、藥物發現和開發、食品和環境檢測、法醫學及臨床研究工作。

　　SCIEX 擁有 40 多年的創新歷史，擅長通過傾聽客戶心聲和理解客戶不斷變化的需求，開發可靠、靈敏且直觀的解決方案，不斷重新定義常規和復雜分析可以實現的成果。有關詳細信息，請訪問 www.sciex.com.

原英文原文

SCIEX Launches New C100 Biologics Analyzer for High Throughput Glycan Screening

FRAMINGHAM, Mass. --(BUSINESS WIRE)

SCIEX, a global leader in life science analytical technologies, today announced the launch of the new C100HT for qualitative glycan screening in biopharma. Combined with SCIEX’s award-winning fast glycan chemistry, the C100HT enables researchers challenged by time-consuming sample preparation and data analysis the ability to expand their workflow by hundreds of glycan samples per day obtaining visual actionable data without the need for time consuming interpretation.

SCIEX C100HT high throughput glycan screening technology is based on advanced capillary electrophoresis hardware armed with user-friendly software, an assay kit configured for up to 1000 separations, and a 12 capillary reagent cartridge for parallel processing of samples. Glycan acceptance criteria can be put in the intuitive analysis dashboard enabling a pass/fail result to be viewed at a glance and decisions on clone selection and cell line optimization to be made in real-time. The C100HT comes complete with a mobile lab bench allowing researchers full flexibility within their own facilities to locate the analytics at the point of decision making.

The C100HT sample preparation chemistry allows preparation of 96 samples in less than 2 hours enabling clones to be selected from large sample populations quickly and cell culture optimization to be performed in real time to significantly increase the likelihood of selecting the best clones and manufacturing conditions. Automated glycan identification eliminates the need for tedious glycan database searches, thus minimizing the potential for human error and optimizing the workflow.

“Being able to select clones and cell culture conditions using information other than titer allows for an enhanced capability where larger populations can be screened, providing better information with which to choose and develop impactful biologics,” said Mark Lies, Senior Product Manager at SCIEX. “Glycan screening is an important part of the process, but it has been limited by how many clones can be screened, not to mention the ensuing data. The C100HT represents a solution to this challenge and includes simplified sample preparation, an instrument of straight forward design, and meaningful visual data analysis, enabling researchers to improve their workflow throughput wherever their samples are generated, leading to fast answers for fast decision making.”

SCIEX’s Fast Glycan Labeling and Analysis technology was awarded the 2016 BioProcess International (BPI) “Award for Best Technology Application – Analytical” for demonstrating increased functionality in novel combinations with other analytical technologies.

Learn more about the new C100HT.

About SCIEX

SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research.

With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit sciex.com.