ChREBPregulationbycarbohydratesandcAMP
Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through transcriptional regulation by the glucose responsive transcription factor ChREBP. ChREBP, carbohydrate responsive element binding protein, is a transcription factor that is activated by high levels of carbohydrates and repressed by cAMP. The activation of ChREBP by elevated ......閱讀全文
ChREBP－regulation－by－carbohydrates－and－cAMP
Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through trans
Regulation－And－Function－Of－ChREBP－in－Liver
Liver is the major site for carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis). While insulin was lo
cAMP分析－cAMP－Assays
cAMP AssaysGouzel Karimova and Daniel LadantUnite Postulante de Biochimie des Interactions Macromoleculaires, Departement de Biologie Structurale et C
CAMP試驗
? (1)原理：B群鏈球菌(無乳鏈球菌)產生一種“CAMP”因子，可促進葡萄球菌的β-溶血素溶解紅細胞的活性。因此，可在兩種細菌(B群鏈球菌和葡萄球菌)的交界處溶血力增強，出現半月型透明溶血區。 (2)培養基：血瓊脂平板。 (3)方法：在羊血或馬血瓊脂平板上，先以產β-溶血素的金黃色葡萄球菌劃一
Regulation－of－hematopoiesis－by－cytokines
The process of hematopoesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the
Regulation－of－BAD－phosphorylation
The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites re
Regulation－of－Spermatogenesis－by－CREM
The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcription
Cyclins－and－Cell－Cycle－Regulation
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted f
Regulation－of－transcriptional－activity－by－PML
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptos
Regulation－of－PGC1a
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl
Regulation－of－eIF2
Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi
CDK－Regulation－of－DNA－Replication
Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events t
Stress－Induction－of－HSP－Regulation
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
Sprouty－regulation－of－tyrosine－kinase－signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
Role－of－Ran－in－mitotic－spindle－regulation
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes
FXR－and－LXR－Regulation－of－Cholesterol－Metabolism
Cholesterol is essential for life and a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol
Role－of－nicotinic－acetylcholine－receptors－in－the－regulation－of－apoptosis
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
Transcription－Regulation－by－Methyltransferase－of－CARM1
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Signal－Dependent－Regulation－of－Myogenesis－by－Corepressor－MITR
The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds t
Regulation－of－Splicing－through－Sam68
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional reg
BTG－family－proteins－and－cell－cycle－regulation
BTG2 is found to be one of the immediate early genes up-regulated by neural growth factor (NGF) and epidermal growth factor (EGF). Its transcriptional
CARM1－and－Regulation－of－the－Estrogen－Receptor
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Ghrelin:－Regulation－of－Food－Intake－and－Energy－Homeostasis
The somatotropic axis. The synthesis and release of growth hormone (GH) from the pituitary are controlled by the hypothalamic hormones GH-releasing ho
Regulation－of－cell－cycle－progression－by－Plk3
The focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading t
如何定量檢測cAMP和cGMP？
背景介紹? 1958年Sutherland發現了cAMP(環磷酸腺苷)，并因此獲得了1971年諾貝爾生理與醫學獎[1].?1963年Ashman發現了cGMP（環磷酸鳥苷）[2]。50年過去了，人們已明白cAMP、cGMP是在很多生理過程中發揮重要調節作用的第二信使分子。鳥苷酸環化酶可將GTP催化生
歐盟評估蘋果果實細胞培養生物質作為新型食品的安全性
2023年7月24日，據歐盟食品安全局（EFSA）消息，歐盟營養、新型食品和食物過敏源（NDA）研究小組就蘋果果實細胞培養生物質（apple fruit cell culture biomass）作為新型食品的安全性發表科學意見。 經過評估，專家小組得出結論，在建議的使用水平下，其作為新型食品
Multistep－Regulation－of－Transcription－by－Pitx2
Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated t
Regulation－of－MAP－Kinase－Pathways－Through－Dual－Specificity－Phosphatases
Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of
Overview－of－telomerase－RNA－component－gene－hTerc－Transcriptional－Regulation
Telomerase is an enzyme which replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells which have an unlimited replica
Mechanism－of－Gene－Regulation－by－Peroxisome－Proliferators－via－PPARa(alpha)
The most recognized mechanism by which peroxisome proliferators regulated gene expresssion is through a PPAR/RXR heterodimeric complex binding to a pe