RoleofEGFReceptorTransactivationbyGPCRsinCardiacHypertrophy
One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickness of the ventricular walls. Cardiac hypertrophy allows the heart to handle the increased stress caused by elevated blood pressure but is also a risk factor associated with heart disease. Cardiac hypertrophy results from cross-talk between G-protein coupled receptor si......閱讀全文
Role－of－EGF－Receptor－Transactivation－by－GPCRs－in－Cardiac－Hypertrophy
One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickn
Bioactive－Peptide－Induced－Signaling－Pathway
Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pres
NFAT－and－Hypertrophy－of－the－heart－(Transcription－in－the－broken－heart)
Hypertrophy associated with both hypertension and obstruction to ventricular outflow leads to pathologic cardiac growth and it is associated with incr
無創血壓計應用論文：動物用血壓計（五）
FIG. 4.Aberrant gene expression patterns of cardiac remodeling factors in ARKO male mice with or without Ang II stimulation. The left panel demons
無創血壓計應用論文：動物用血壓計（一）
Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis?【摘要】? Androg
無創血壓計應用論文：動物用血壓計（四）
Ang II-stimulated Cardiac Dysfunction in ARKO Male Mice-We also evaluated the cardiac performance of these mice using echocardiography. Although l
Neuroregulin－receptor－degredation－protein1－Controls－ErbB3－receptor
The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, i
arrestins－in－GPCR－Desensitization
Role of ?-arrestins in the desensitization, sequestration and intracellular trafficking of GPCRs. Homologous desensitization of GPCRs (1) results from
Corticosteroids－and－cardioprotection
Myocardial infarction damages heart tissue both during the initial ischemia and the subsequent reperfusion of tissues with oxygen. Corticosteroids can
CBL－mediated－ligandinduced－downregulation－of－EGF－receptors
As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, dese
ALK－in－cardiac－myocytes
Heart formation is cued by a combination of positive and negative signals from surrounding tissues. Inhibitory signals that block heart formation in a
無創血壓計應用論文：動物用血壓計（三）
TABLE IPrimer sequences for mRNA analyses Sequences are listed 5' to 3'.Quantitative Real-time PCR by SYBR Green Detection Method-The mRNA l
Hop－Pathway－in－Cardiac－Development
Homeodomain transcription factors comprise a large family of DNA binding factors that regulate transcription and development. Many homeodomain genes a
Aspirin－Blocks－Signaling－Pathway－Involved－in－Platelet－Activation
Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4
GMEB1基因編碼功能及結構描述
該基因編碼一個與gmeb2蛋白相關的kdwk基因家族成員。gmeb1-gmeb2復合物是細小病毒dna復制的關鍵。在大鼠體內對類似基因的研究表明，該基因的作用是調節糖皮質激素受體與糖皮質激素反應元件結合時的反式激活。存在三種不同編碼亞型的剪接轉錄變體。[由RefSeq提供，2016年2月]This
GMEB1基因突變與藥物因子介紹
該基因編碼一個與gmeb2蛋白相關的kdwk基因家族成員。gmeb1-gmeb2復合物是細小病毒dna復制的關鍵。在大鼠體內對類似基因的研究表明，該基因的作用是調節糖皮質激素受體與糖皮質激素反應元件結合時的反式激活。存在三種不同編碼亞型的剪接轉錄變體。[由RefSeq提供，2016年2月]This
GMEB1基因編碼功能及結構描述
該基因編碼一個與gmeb2蛋白相關的kdwk基因家族成員。gmeb1-gmeb2復合物是細小病毒dna復制的關鍵。在大鼠體內對類似基因的研究表明，該基因的作用是調節糖皮質激素受體與糖皮質激素反應元件結合時的反式激活。存在三種不同編碼亞型的剪接轉錄變體。[由RefSeq提供，2016年2月]This
Differentiate－ES－cells－into－cardiac－myocytes
Day -1:?Pass ES cells at normal density on gelatinized plate to free the culture of contamination fibroblast cells.____________________Day 1:?Trypsini
Primary－cardiac－fibroblast－and－cardiomyocyte－isolation
1.?Ventricles were removed under sterile conditions. 2.?Ventricles were placed in cold sterile primary cell culture medium, minced into approximat
Isolation－of－rat－cardiac－fibroblasts－and－cardiomyocytes
1.?Hearts were removed from newborn rats (day 0), put into calcium- and bicarbonate-free HEPES-buffered Hanks’ medium, cut into pieces and digeste
ECSCR基因編碼功能及結構描述
該基因編碼的蛋白質主要存在于內皮細胞和血管中，參與細胞形態變化和表皮生長因子誘導的細胞遷移。能增強血管內皮生長因子受體-2/激酶插入結構域受體的活化，并促進內化激酶插入結構域受體的蛋白水解。該基因可能在血管生成相關疾病中發揮作用。選擇性剪接導致多個轉錄變體。The protein encoded b
ECSCR基因突變與藥物因子介紹
該基因編碼的蛋白質主要存在于內皮細胞和血管中，參與細胞形態變化和表皮生長因子誘導的細胞遷移。能增強血管內皮生長因子受體-2/激酶插入結構域受體的活化，并促進內化激酶插入結構域受體的蛋白水解。該基因可能在血管生成相關疾病中發揮作用。選擇性剪接導致多個轉錄變體。The protein encoded b
Eph－Kinases－and－ephrins－support－platelet－aggregation
Eph kinases are a family of receptor tyrosine kinases with an extracellular domain that binds their ligand, the ephrins, and an intracellular kinase d
Pertussis－toxininsensitive－CCR5－Signaling－in－Macrophage
The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV inf
Role－of－Mitochondria－in－Apoptotic－Signaling
Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein
Control－of－skeletal－myogenesis－by－HDAC－calcium/calmodulindependent－kinase
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My
EGF－Signaling－Pathway
The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kinase cytoplasmic domain, a s
Trka－Receptor－Signaling－Pathway
Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine k
B－Cell－Receptor－Complex
B cells produce immunoglobulins (Ig, antibodies) that specifically bind antigen molecules. B cells first produce a membrane-bound form of immunoglobul
Chromatin－Remodeling－by－hSWI/SNF－ATPdependent－Complexes
The eukaryotic genome is packaged by histone and nonhistone proteins to form chromatin. The assembly of nucleosomesas well as compaction of nucleosoma