TheRoleofEosinophilsintheChemokineNetworkofAllergy
The inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to the regulated local production of chemoattractant molecules . Although several chemical mediators are active upon eosinophils in vitro, a central role in eosinophil accumulation in vivo is emerging for the C-C chemokine eotaxin, which was first identified in a guinea p......閱讀全文
The－Role－of－Eosinophils－in－the－Chemokine－Network－of－Allergy
The inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to
CCR3－signaling－in－Eosinophils
Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response
Cytokine－Network
Several different cell types coordinate their efforts as part of the immune system, including B cells, T cells, macrophages, neutrophils, basophils an
Cytokines－and－Inflammatory－Response
Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coord
Role－of－Mitochondria－in－Apoptotic－Signaling
Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein
Endocytotic－role－of－NDK,－Phosphins－and－Dynamin
Reliable neurotransmitter release requires the presence of sufficent numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) i
Role－of－Ran－in－mitotic－spindle－regulation
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes
CXCR4－Signaling－Pathway
CXCR4 is a chemokine receptor in the GPCR gene family, and is expressed by cells in the immune system and the central nervous system. In response to b
Allergy：你是易過敏的人嗎？
近期發表在Allergy的研究稱，出生季節與過敏風險有關，尤其是秋冬季出生的人，風險更高。 英國南安普頓大學的研究人員對出生在英國懷特島的南部海岸的367名人群的DNA樣本進行了表觀遺傳掃描。 在對參與者進行全血廣泛的表觀表觀基因組DNA檢測后，研究人員發現，DNA甲基化與出生季節有關，就算
Selective－expression－of－chemokine－receptors－during－Tcell－polarization
Chemokine receptors expressed by T helper cells help recruit cells to specific locations based on their chemoattractant ligands. The polarization of T
fMLP－induced－chemokine－gene－expression－in－HMC1－cells
Neutrophils respond to bacterial infection by releasing reactive oxygen species that kill bacteria and by expressing chemokines that attract other imm
Role－of－Erk5－in－Neuronal－Survival
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a
Role－of－Tob－in－Tcell－activation
Regulation of T cell activation is a crucial component of balanced functioning of the immune system. If the T cell response is too great and activatio
Role－of－Parkin－in－the－UbiquitinProteasomal－Pathway
The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons i
Role－of－nicotinic－acetylcholine－receptors－in－the－regulation－of－apoptosis
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
Ion－Channels－and－Their－Functional－Role－in－Vascular－Endothelium
Endothelial cells (EC) form a multifunctional signal-transducing surface that performs different tasks dependent on its localization in the vessel tre
Role－of－arrestins－in－the－activation－and－targeting－of－MAP－kinases
The binding of ?-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using ?-arrestin as a scaffold, with sub
Pertussis－toxininsensitive－CCR5－Signaling－in－Macrophage
The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV inf
The－role－of－FYVEfinger－proteins－in－vesicle－transport
Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling syste
Role－of－ERBB2－in－Signal－Transduction－and－Oncology
Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the
AKAP95－role－in－mitosis－and－chromosome－dynamics
The chromatin packaging of the genome is dynamic, changing with the cell cycle and with transcriptional regulation. During mitosis, chromatin is conde
Role－of－PPARgamma－Coactivators－in－Obesity－and－Thermogenesis
Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPAR-gamma is a member of t
Role－of－MAL－in－RhoMediated－Activation－of－SRF
Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including (i)i
Role－of－EGF－Receptor－Transactivation－by－GPCRs－in－Cardiac－Hypertrophy
One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickn
CXCL8基因突變與藥物因子介紹
該基因編碼的蛋白是CXC趨化因子家族的一員，是炎癥反應的主要介質編碼的蛋白質主要由中性粒細胞分泌，在中性粒細胞中，它通過引導中性粒細胞到達感染部位起到趨化因子的作用。這種趨化因子也是一種有效的血管生成因子。該基因被認為在毛細支氣管炎（一種由病毒感染引起的常見呼吸道疾病）的發病機制中起作用。該基因和C
CXCL8基因編碼功能及結構描述
該基因編碼的蛋白是CXC趨化因子家族的一員，是炎癥反應的主要介質編碼的蛋白質主要由中性粒細胞分泌，在中性粒細胞中，它通過引導中性粒細胞到達感染部位起到趨化因子的作用。這種趨化因子也是一種有效的血管生成因子。該基因被認為在毛細支氣管炎（一種由病毒感染引起的常見呼吸道疾病）的發病機制中起作用。該基因和C
JAMA－Network－Open：細胞衰老會伴隨大腦結構的改變
端粒是染色體末端的保護帽，它會隨著細胞分裂而變短。如果端粒長度變得太短，以至于它們所保護的基因可能被破壞，那么細胞就會停止分裂和更新。這種機制是我們機體衰老的方式之一。 因此，端粒長度被認為是一個人的生物學年齡的標志。對于兩個具有相同年齡的人，端粒較短的人患與年齡有關的疾病的風險增加，甚至壽命
Allergy：過敏免疫治療可減緩哮喘的進展
根據近日發表在《過敏》(Allergy)網絡版上的一項研究，過敏免疫療法(AIT)與降低哮喘進展的風險有關，尤其是在年輕患者中效果更明顯。 德國德累斯頓工業大學的公共衛生學碩士Jochen Schmitt及其同事利用德國醫療保險數據(2005年至2014年)，基于全球哮喘倡議(GINA)制定的
Pediatric－Allergy－Immunol：早期環境會調節機體免疫反應
過去幾十年來，過敏性疾病的患病率顯著增加，造成了巨大的經濟和社會負擔。因此，研究人員正試圖發現預防和治療這些疾病的新方法。東芬蘭大學的一篇新的論文表明，免疫反應與早期生活多樣化之間存在聯系，如產科因素，農場塵埃和空氣污染。在青春期之前，可以看到免疫反應的一些變化。（圖片來源：www.pixaba
Role－of－MEF2D－in－Tcell－Apoptosis
Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell Calcium Induced Apoptosis. Several factors regulate Mef2 transcription fa