TollLikeReceptorPathway
The innate immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS, endotoxin), bacterial lipoproteins, peptidoglycans and also CpG nucleic acids activate innate immunity as well as stimulating the antigen-specific immune response and triggering the inflammatory response. Members of the toll-like receptor (TLR) gene family convey signal......閱讀全文
TollLike－Receptor－Pathway
The innate immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS,
Trka－Receptor－Signaling－Pathway
Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine k
T－Cell－Receptor－Signaling－Pathway
The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alph
Msp/Ron－Receptor－Signaling－Pathway
MSP, macrophage-stimulating protein, acts through the transmembrane receptor kinase RON (Stk in mice) to play a role in inflammation and the response
IL22－Soluble－Receptor－Signaling－Pathway
IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surfa
NFkB－activation－by－Nontypeable－Hemophilus－influenzae
The role of Hemophilus influenzae in ear infections and chronic obstructive pulmonary disease includes the induction of an inflammatory response throu
Inactivation－of－Gsk3－by－AKT－causes－accumulation－of－bcatenin
Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria i
Signal－transduction－through－IL1R
Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include i
Dendritic－cells－in－regulating－TH1－and－TH2－Development
While T cells and B cells carry out the actions of antigen-specific immune responses, antigen-presenting cells called dendritic cells are required for
共表達分析挖掘lncRNA的生物學功能
lncRNA研究是目前生命科學領域的研究熱點，但是，目前對于lncRNA的功能理解還處于初級階段。據不完全統計，目前已知功能的lncRNA不超過1000條。因此，怎么在現有基礎上去挖掘lncRNA的生物學功能呢？針對lncRNA和mRNA的共表達研究，為我們理解lncRNA在疾病中的生物學功能提
共表達分析挖掘lncRNA的生物學功能
lncRNA研究是目前生命科學領域的研究熱點，但是，目前對于lncRNA的功能理解還處于初級階段。據不完全統計，目前已知功能的lncRNA不超過1000條。因此，怎么在現有基礎上去挖掘lncRNA的生物學功能呢？針對lncRNA和mRNA的共表達研究，為我們理解lncRNA在疾病中的生物學功能提
共表達分析挖掘lncRNA的生物學功能
lncRNA研究是目前生命科學領域的研究熱點，但是，目前對于lncRNA的功能理解還處于初級階段。據不完全統計，目前已知功能的lncRNA不超過1000條。因此，怎么在現有基礎上去挖掘lncRNA的生物學功能呢？針對lncRNA和mRNA的共表達研究，為我們理解lncRNA在疾病中的生物學功能提供了
LRRFIP2基因編碼功能及結構描述
該基因編碼的蛋白與myd88結合在toll樣受體4（tlr4）的胞漿末端，從而激活核因子kappa b信號傳導。泛素樣蛋白fat10阻止編碼蛋白與tlr4的相互作用，從而使核因子kappa b信號途徑失活。此外，這種蛋白可以通過將caspase-1抑制劑flightless-i招募到炎癥復合物中來下
LRRFIP2基因突變與藥物因子介紹
該基因編碼的蛋白與myd88結合在toll樣受體4（tlr4）的胞漿末端，從而激活核因子kappa b信號傳導。泛素樣蛋白fat10阻止編碼蛋白與tlr4的相互作用，從而使核因子kappa b信號途徑失活。此外，這種蛋白可以通過將caspase-1抑制劑flightless-i招募到炎癥復合物中來下
Neuroregulin－receptor－degredation－protein1－Controls－ErbB3－receptor
The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, i
B－Cell－Receptor－Complex
B cells produce immunoglobulins (Ig, antibodies) that specifically bind antigen molecules. B cells first produce a membrane-bound form of immunoglobul
The－IGF1－Receptor－and－Longevity
A demonstrated means to increase lifespan in a wide range of organisms is through the restriction of caloric intake. Reducing the consumption of calor
Signaling－of－Hepatocyte－Growth－Factor－Receptor
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
Dicer－Pathway
The degradation of endogenous mRNA in a sequence-specific manner can be induced by dsRNA [RNA interfernce (RNAi)], antisense transcription, or viral i
Fibrinolysis－Pathway
Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer forma
Complement－Pathway
The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement syste
Antisense－Pathway
About 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense R
Prion－Pathway
Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded
Glycolysis－Pathway
Glycolysis was one of the first metabolic pathways studied and is one of the best understood, in terms of the enzymes involved, their mechanisms of ac
B－Cell－Receptor－信號通路圖
B cells produce immunoglobulins (Ig, antibodies) that specifically bind antigen molecules. B cells first produce a membrane-bound form of immunogl
T－Cell－Receptor－信號通路圖
The ?T Cell Receptor plays a key role in the immune system. The specificity ?of the receptor is governed by the binding site formed from the mature ?a
Control－of－Gene－Expression－by－Vitamin－D－Receptor
The vitamin D receptor, VDR is the mediator of all genomic actions of vitamin D3 and its analogs. It belongs to a family of ligand induced transcripti
CARM1－and－Regulation－of－the－Estrogen－Receptor
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
WNT－Signaling－Pathway
Wnt family members are secreted glycoproteins who bind to cell surface receptors such as Frizzled. Wnt members can play a role in the expression of ma
Phosphatidylcholine－Biosynthesis－Pathway
The main components of biological membranes are phosphoglyceride lipids composed of a glycerol unit esterified to two fatty acids and a polar alcohol